Effect of Histone Terminal Domains on Chromatin Structural Transitions


According to theoretical estimations, the tertiary conformation of a nucleosome fiber depends on parameters of the nucleosome–nucleosome linker system, including the rotation angle between adjacent nucleosomes. We studied the effect of histones with modified primary structure on chromatin-fiber folding; ethidium bromide was used to measure the internucleosome DNA axial twist. It was found that hyperacetylation of histone terminal domains and their selective enzymatic removal led to specific structural transitions in chromatin fibers because of changes in the linker DNA twist.

DOI: 10.1023/A:1011556529349

2 Figures and Tables

Cite this paper

@article{Krajewski2001EffectOH, title={Effect of Histone Terminal Domains on Chromatin Structural Transitions}, author={V. A. Krajewski and Marya A Lagarkova and Natalia P. Sharova and S. D. Stoliarov and Juan Ausi{\'o}}, journal={Doklady Biochemistry and Biophysics}, year={2001}, volume={377}, pages={132-134} }