Effect of Histamine H2-Receptor Antagonists on Vitamin B12 Absorption

  title={Effect of Histamine H2-Receptor Antagonists on Vitamin B12 Absorption},
  author={R. Force and M. Nahata},
  journal={Annals of Pharmacotherapy},
  pages={1283 - 1286}
  • R. Force, M. Nahata
  • Published 1992
  • Chemistry, Medicine
  • Annals of Pharmacotherapy
  • OBJECTIVE: To discuss the potential of histamine H2-receptor antagonists (H2RAs) to cause malabsorption of vitamin B12 (cyanocobalamin). DATA SOURCES: Pertinent literature was identified via a MEDLINE search. Journals and references cited in published articles also were used as data sources. STUDY SELECTION: Studies evaluating the effect of H2RAs on vitamin B12 absorption were reviewed. DATA SYNTHESIS: H2RAs decrease acid secretion by the gastric parietal cells. Gastric acid and pepsin produced… CONTINUE READING
    32 Citations
    Omeprazole and Vitamin B12 Deficiency
    • 34
    Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels?
    • 2
    • PDF
    Age-Related Changes in Cobalamin (Vitamin B12) Handling
    • 64
    Vitamin B 12 as a Treatment for Pain
    • 1


    Metabolic consequences of reduced gastric acidity.
    • 12
    Effect of cimetidine on the absorption of vitamin B12.
    • 65
    The effect of ranitidine on the absorption of food cobalamins.
    • 18
    Malabsorption of vitamin B12 after vagotomy.
    • 41
    Inhibition of gastric secretion in man with a new H2-receptor antagonist, ranitidine.
    • 35