Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease.

@article{Moss1992EffectOH,
  title={Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease.},
  author={Steven F. Moss and Steve Legon and Anne E. Bishop and Julia M P Polak and John Calam},
  journal={Lancet},
  year={1992},
  volume={340 8825},
  pages={930-2}
}
Infection of the gastric antrum by Helicobacter pylori is associated with recurrent duodenal ulcer disease but the mechanism of ulcerogenesis is unclear. Since pathways inhibiting gastric secretion are defective in patients with duodenal ulcers, we investigated whether H pylori interferes with the normal gastric inhibition that is mediated by somatostatin. We studied 28 patients with active duodenal ulcers in whom H pylori was eradicated successfully. In 18 patients, we measured the density of… CONTINUE READING