Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells.

@article{Terebiznik2009EffectOH,
  title={Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells.},
  author={Mauricio R Terebiznik and D. Kumaran Raju and Cristina Lourdes V{\'a}zquez and Karl Torbricki and Reshma Kulkarni and Steven Robert Blanke and Tamotsu Yoshimori and Mar{\'i}a Isabel Colombo and Nicola Louise Jones},
  journal={Autophagy},
  year={2009},
  volume={5 3},
  pages={370-9}
}
Host cell responses to Helicobacter pylori infection are complex and incompletely understood. Here, we report that autophagy is induced within human-derived gastric epithelial cells (AGS) in response to H. pylori infection. These autophagosomes were distinct and different from the large vacuoles induced during H. pylori infection. Autophagosomes were detected by transmission electron microscopy, conversion of LC3-I to LC3-II, GFP-LC3 recruitment to autophagosomes, and depended on Atg5 and Atg12… CONTINUE READING