Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors

@inproceedings{Kobayashi1995EffectOH,
  title={Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors},
  author={Hiroyuki Kobayashi and Yuzuru Takemura and Hayato Miyachi and Lorraine A Skelton and Ann L. Jackman},
  booktitle={Japanese journal of cancer research : Gann},
  year={1995}
}
One of the resistance mechanisms to folate-based thymidylate synthase (TS) inhibitors is the increase in TS activity in tumor cells. Human B lymphoblastoid cell line (W1L2) was made resistant to a lipophilic non-polyglutamatable TS inhibitor (ZM249148), and the subline (W1L2:R179) showed a 20-fold increase in TS enzyme activity with concomitant… CONTINUE READING