• Medicine
  • Published 2008

Effect of HMGB1 and expression of TLR-4 in renal injury of SLE

@inproceedings{Shu2008EffectOH,
  title={Effect of HMGB1 and expression of TLR-4 in renal injury of SLE},
  author={Liu Shu},
  year={2008}
}
Objective:To investigate the effect of HMGB1 and TLR-4 in the renal injury of SLE.Methods:The level of HMGB1 in serum from 16 patients suffering from SLE without kidney damage,18 patient with lupus nephritis (LN),and 12 healthy individuals were measured by ELISA.The fresh PBMCs were isolated and the total RNA was extracted.Then the mRNA expression of HMGB1 was amplified by RT-PCR.Flow cytometric analysis(FCM) was performed to study cell surface markers and the expression of TLR-4.Results:RT-PCR… CONTINUE READING

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