Effect of HMG-CoA reductase inhibitors on vascular cell apoptosis: beneficial or detrimental?

@article{Katsiki2010EffectOH,
  title={Effect of HMG-CoA reductase inhibitors on vascular cell apoptosis: beneficial or detrimental?},
  author={Niki Katsiki and Konstantinos Tziomalos and Yiannis S. Chatzizisis and Moses C Elisaf and Apostolos Hatzitolios},
  journal={Atherosclerosis},
  year={2010},
  volume={211 1},
  pages={9-14}
}
Vascular cell apoptosis, an active form of programmed cell death, plays an integral role in atherosclerosis and in-stent restenosis after angioplasty, thus promoting the precipitation of acute cardiovascular events. Beyond their cholesterol-lowering effects, HMG-CoA reductase inhibitors, or statins, have been persistently reported to influence the apoptotic process. In this review we discuss the effect of statin treatment on vascular cell apoptosis, and therefore on atherosclerosis development… CONTINUE READING