Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection.

@article{Harcourt2001EffectOH,
  title={Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection.},
  author={Gillian C Harcourt and Simon Hellier and Michael Bunce and Jack Satsangi and Jane Collier and Russell L. Chapman and Rodney Phillips and Paul Klenerman},
  journal={Journal of viral hepatitis},
  year={2001},
  volume={8 3},
  pages={174-9}
}
Hepatitis C virus (HCV) infection is very common worldwide, but has a broad range of outcomes. A minority of patients are able to clear infection spontaneously, and this is thought to be due to the emergence and maintenance of effective cell-mediated immunity, particularly CD4+ T lymphocyte responses. Furthermore, genetic studies have indicated that HLA class II genotype strongly influences the outcome of infection. We have therefore investigated the influence of the protective HLA class II… CONTINUE READING

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