Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience.

@article{Petersdorf2001EffectOH,
  title={Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience.},
  author={Effie W. Petersdorf and Craig Kollman and Carolyn Katovich Hurley and B J Dupont and Auyaporn Nademanee and Ann B. Begovich and Daniel H Weisdorf and Philip McGlave},
  journal={Blood},
  year={2001},
  volume={98 10},
  pages={2922-9}
}
The clinical importance of HLA class II gene disparity in unrelated stem cell transplantation is not entirely known. The impact was evaluated of matching donors and recipients for HLA-DR, HLA-DQ, and HLA-DP genes on clinical outcome after stem cell transplantation for chronic myeloid leukemia (CML) performed between 1988 and 1997. HLA-DRB1, -DQA1, -DQB1, -DPA1, and -DPB1 alleles were identified in 831 transplant pairs using a combination of sequence-specific oligonucleotide probes, sequence… CONTINUE READING