Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations.

@article{Andersson2016EffectOH,
  title={Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations.},
  author={Anne-Marie Carola Andersson and Emeline Ragonnaud and Kelly E Seaton and Sheetal Sawant and Antonella Folgori and Stefano Colloca and Celia C LaBranche and David C. Montefiori and Georgia D. Tomaras and Peter Johannes Holst},
  journal={Vaccine},
  year={2016},
  volume={34 44},
  pages={5344-5351}
}
The low number of envelope (Env) spikes presented on native HIV-1 particles is a major impediment for HIV-1 prophylactic vaccine development. We designed virus-like particle encoding adenoviral vectors utilizing SIVmac239 Gag as an anchor for full length and truncated HIV-1 M consensus Env. Truncated Env overexpressed VRC01 and 17b binding antigen on the surface of transduced cells while the full length Env vaccine presented more and similar amounts of antigen binding to the trimer conformation… CONTINUE READING
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