Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study

@article{Whitworth2000EffectOH,
  title={Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study},
  author={James A Whitworth and Dilys Morgan and Maria A Quigley and Adrian Smith and Billy Nsubuga Mayanja and Henry Eotu and Nicholas Omoding and Martins Okongo and Samuel Sewava Malamba and Amato Ojwiya},
  journal={The Lancet},
  year={2000},
  volume={356},
  pages={1051-1056}
}
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483 Citations
Highly Influential Citations
24
Background Citations
166
Methods Citations
5
Results Citations
24

483 Citations

Citation Type

Citation Type

Association of HIV-Induced Immunosuppression and Clinical Malaria in Nigerian Adults.
TLDR
More aggressive malaria control measures are highly needed in severely immunosuppressed HIV-infected patients in Nigeria after an inverse relationship between CD4 cell count and parasite density was demonstrated.
Impact of HIV-associated immunosuppression on malaria infection and disease in Malawi.
TLDR
Profoundly Immunosuppressed adults with HIV infection require more-frequent treatment for uncomplicated malaria, but malaria infection and disease are less strongly associated with HIV-associated immunosuppression than are other opportunistic infections.
Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults
TLDR
Data support an interaction between symptomatic P. falciparum and HIV, and suggest an additional HIV-related public health problem in Africa.
HIV-1 Infection in Patients Referred for Malaria Blood Smears at Government Health Clinics in Uganda
TLDR
In Ugandans evaluated for suspected malaria, associations between malaria smear results and HIV infection differed between children and adults, suggesting that counseling and testing for HIV may be of particular importance in children suspected of malaria but with negative malaria smear and in adults with positive malaria smears.
HIV and parasitic co-infections among patients seeking care at health facilities in Tanzania.
TLDR
High prevalence of malaria and helminth co-infection in HIV-infected individuals is found and mass treatment of soil transmitted helminths can be incorporated into HIV/AIDS management programmes.
HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria.
TLDR
HIV-1-infected patients with malaria with a CD4 cell count <300 cells/microL have a higher risk of experiencing a recrudescent infection, compared with those with aCD4 cell number >or=300 cells /microL or without HIV-1 infection.
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
TLDR
The HIV-1 seroprevalence rate was surprisingly high in adults presenting with malaria, and this finding supports the implementation of routine HIV counseling and testing for adults with uncomplicated falciparum malaria.
Increased prevalence of severe malaria in HIV-infected adults in South Africa.
  • C. Cohen, A. Karstaedt, H. Crewe-Brown
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
TLDR
HIV-infected nonimmune adults are at increased risk of severe malaria, and this risk is associated with a low CD4+ T cell count.
A Study of Malaria Parasite Density in HIV-1 Positive Under-fives in Benin City, Nigeria
TLDR
Parasitaemia is higher in HIV-infected than uninfected children and the burden is highest at infancy, while acquisition of antimalarial immunity is similar in both groups.
HIV-malaria interactions in North-East India: A prospective cohort study
TLDR
The study showed no significant increase in HIV viral load in malaria cases and there was 100 per cent adequate clinical and parasitological response (ACPR) after treating with artemisinin based combination therapy (ACT) both in HIV-infected and HIV-uninfected P. falciparum malaria-positive individuals.
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