Effect of Glucose Concentration on Formation of AGEs in Erythrocytes in Vitro

@article{Nagai2005EffectOG,
  title={Effect of Glucose Concentration on Formation of AGEs in Erythrocytes in Vitro},
  author={Ryoji Nagai and Elizabeth K. Deemer and Jonathan W. C. Brock and Suzanne R. Thorpe and John W. Baynes},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1043}
}
Abstract: Posttranslational modifications, such as advanced glycoxidation and lipoxidation end products (AGE/ALEs), are implicated in the pathogenesis of diabetic complications and atherosclerosis. Recent studies have demonstrated that AGE/ALEs are generated not only in extracellular matrix proteins, but also in intracellular proteins from metabolic intermediates. In this study we investigate the effect of glucose concentration on the formation of the AGE/ALEs, Nε‐(carboxymethyl)lysine (CML), N… Expand
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