Effect of Glucocorticoid Therapy on Glucocorticoid Receptors in Children with Autoimmune Diseases

@article{Andreae2001EffectOG,
  title={Effect of Glucocorticoid Therapy on Glucocorticoid Receptors in Children with Autoimmune Diseases},
  author={Judit Andreae and Robert Tripmacher and Renita Weltrich and Wolfgang Rohde and Rolf Keitzer and Ulrich Wahn and Karl Paul and Frank Buttgereit},
  journal={Pediatric Research},
  year={2001},
  volume={49},
  pages={130-135}
}
Low-dose glucocorticoids (GC) achieve their action completely by classical genomic effects, mediated by the glucocorticoid receptor (GCR). In high doses of GC, nongenomic effects have also been found, but it is still unclear to what extent they contribute to a beneficial outcome. In this study, we present a determination of the number of lymphocyte GCR sites and the binding affinity in healthy children and children with autoimmune diseases. We further assess the effect of GC administration… CONTINUE READING

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