Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects.

@article{Robertson2008EffectOG,
  title={Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects.},
  author={Sarah M. Robertson and Richard T Davey and Jocelyn Voell and Elizabeth Formentini and Raul M. Alfaro and Scott R. Penzak},
  journal={Current medical research and opinion},
  year={2008},
  volume={24 2},
  pages={
          591-9
        }
}
OBJECTIVE Animal and in vitro data suggest that Ginkgo biloba extract (GBE) may modulate CYP3A4 activity. As such, GBE may alter the exposure of HIV protease inhibitors metabolized by CYP3A4. It is also possible that GBE could alter protease inhibitor pharmacokinetics (PK) secondary to modulation of P-glycoprotein (P-gp). The primary objective of the study was to evaluate the effect of GBE on the exposure of lopinavir in healthy volunteers administered lopinavir/ritonavir. Secondary objectives… Expand
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