Effect of General Anesthesia in Infancy on Long-Term Recognition Memory in Humans and Rats

@article{Stratmann2014EffectOG,
  title={Effect of General Anesthesia in Infancy on Long-Term Recognition Memory in Humans and Rats},
  author={G. Stratmann and Joshua Lee and J. Sall and Bradley H Lee and R. Alvi and J. Shih and Allison M Rowe and T. M. Ramage and F. L. Chang and T. Alexander and David K Lempert and N. Lin and Kasey H Siu and S. A. Elphick and Alice S. Wong and Caitlin Schnair and Alexander F Vu and J. T. Chan and Huizhen Zai and Michelle K Wong and Amanda Anthony and K. C. Barbour and D. Ben-Tzur and N. E. Kazarian and Joyce Y Lee and Jay R Shen and Eric Liu and Gurbir S Behniwal and C. Lammers and Zoel Quinones and A. Aggarwal and Elizabeth Cedars and A. Yonelinas and S. Ghetti},
  journal={Neuropsychopharmacology},
  year={2014},
  volume={39},
  pages={2275-2287}
}
Anesthesia in infancy impairs performance in recognition memory tasks in mammalian animals, but it is unknown if this occurs in humans. Successful recognition can be based on stimulus familiarity or recollection of event details. Several brain structures involved in recollection are affected by anesthesia-induced neurodegeneration in animals. Therefore, we hypothesized that anesthesia in infancy impairs recollection later in life in humans and rats. Twenty eight children ages 6–11 who had… Expand
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References

SHOWING 1-10 OF 54 REFERENCES
Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys.
TLDR
It is demonstrated that a single 24-h episode of ketamine anesthesia, occurring during a sensitive period of brain development, results in very long-lasting deficits in brain function in primates and provides proof-of-concept that general anesthesia during critical periods of brainDevelopment can result in subsequent functional deficits. Expand
Isoflurane exposure in newborn rats induces long-term cognitive dysfunction in males but not females
TLDR
The profound behavioral impairment in males relative to females, in spite of comparable cell death, suggests that males are more susceptible to long-term cognitive effects and this outcome may not be exclusively attributed to neuronal death. Expand
Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats
TLDR
Delayed environmental enrichment rescued the sevoflurane-induced impairment in short-term memory and generally improved many tested aspects of cognitive function, both in sev ofluran-treated and control animals. Expand
An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory
TLDR
It is found that damage limited to the hippocampus results in a selective deficit in recollection and not familiarity, and that the impairment following prefrontal damage is due to false alarms, likely reflecting a deficit in source monitoring. Expand
Cognitive Aging: A Common Decline of Episodic Recollection and Spatial Memory in Rats
TLDR
The pattern of impairment in recollection and relative sparing of familiarity observed in human cognitive aging to rats is extended and suggested, suggesting a common age-related impairment in both spatial learning and the recollective component of nonspatial recognition memory. Expand
An Assessment of the Effects of General Anesthetics on Developing Brain Structure and Neurocognitive Function
TLDR
The evidence for anesthesia-induced neurodegeneration in animal models is compelling and given the serious implications for public health, further investigations of this phenomenon are imperative, both in laboratory animals and in young children. Expand
Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia
TLDR
Children in this cohort exposed to anesthesia before age 3 had a higher relative risk of language and abstract reasoning deficits at age 10 than unexposed children, indicating that the association between anesthesia and neuropsychological outcome may be confined to specific domains. Expand
Isoflurane Anesthesia Induced Persistent, Progressive Memory Impairment, Caused a Loss of Neural Stem Cells, and Reduced Neurogenesis in Young, but Not Adult, Rodents
  • Changlian Zhu, J. Gao, +6 authors K. Blomgren
  • Psychology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2010
TLDR
Object recognition and reversal learning were significantly impaired in isoflurane-treated young rats and mice, whereas adult animals were unaffected, and these deficits became more pronounced as the animals grew older. Expand
ROC in animals: Uncovering the neural substrates of recollection and familiarity in episodic recognition memory
  • M. Sauvage
  • Medicine, Psychology
  • Consciousness and Cognition
  • 2010
TLDR
This review discusses how adapting standard human recognition memory paradigms to rats, performing circumscribed brain lesions and using receiver operating characteristic (ROC) methods contributed to solve the controversy over familiarity and recollection. Expand
Neurotoxicity of Anesthetic Drugs in the Developing Brain
TLDR
This review gives an overview of some of the mechanisms that have been proposed for anesthesia-induced cognitive decline and discusses possible treatment options, and discusses early results of comparative animal studies of anesthetic neurotoxicity. Expand
...
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5
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