Effect of Gallic Acid on Regression of Murine CCL4-Induced Hepatic Cirrhosis

  title={Effect of Gallic Acid on Regression of Murine CCL4-Induced Hepatic Cirrhosis},
  author={S. Figueiredo and L{\'i}via Maria Della Porta Cosac and C. S. Goncalves and M. J. Augusto and F. Ramalho and L. Ramalho},
Hepatic cirrhosis can be induced by chronic exposure to reactive oxygen species (ROS). However, phenolic compounds, such as gallic acid (GA), appear to inhibit ROS-induced oxidative stress. We aimed to investigate the effects of GA on murine hepatic fibrogenesis. The effects of GA were evaluated on the regression of liver cirrhosis that was induced by chronic intraperitoneal CCl4 administration (20% v/v) in C57 mice for a period of 10 weeks. The animals were treated intraperitoneally and… Expand
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