Effect of GR32191, a potent thromboxane receptor antagonist, on exercise induced bronchoconstriction in asthma.

@article{Finnerty1991EffectOG,
  title={Effect of GR32191, a potent thromboxane receptor antagonist, on exercise induced bronchoconstriction in asthma.},
  author={James P Finnerty and O P Twentyman and Alon Harris and James Dean Palmer and Stephen T. Holgate},
  journal={Thorax},
  year={1991},
  volume={46 3},
  pages={190-2}
}
Previous work suggests a role for mast cell derived mediators in exercise induced asthma. The contribution of newly generated contractile prostaglandins to exercise induced asthma was assessed by using a potent and orally active thromboxane (TP1) receptor antagonist, GR32191. The effect of 120 mg GR32191 on exercise induced asthma was observed in 12 asthmatic subjects. For the exercise challenge the subjects performed six minutes of treadmill exercise, breathing dry air at a work load that had… CONTINUE READING
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