Effect of GIP and GLP-1 antagonists on insulin release in the rat.

@article{Tseng1999EffectOG,
  title={Effect of GIP and GLP-1 antagonists on insulin release in the rat.},
  author={C C Tseng and Xiaoying Zhang and M. Michael Wolfe},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1999},
  volume={276 6},
  pages={E1049-E1054}
}
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are potent insulinotropic peptides released from the small intestine. To examine their relative contribution to postprandial insulin release, a specific GIP antagonist (ANTGIP) and a GLP-1 antagonist, exendin-(9-39)-NH2, were infused into rats after an intragastric glucose meal. In control rats, plasma glucose and insulin levels rose gradually during the first 20 min and then decreased. Exendin-(9-39)-NH2… CONTINUE READING