Effect of GB virus C co-infection on response to generic HAART in African patients with HIV-1 clade C infection

@article{Mosam2007EffectOG,
  title={Effect of GB virus C co-infection on response to generic HAART in African patients with HIV-1 clade C infection},
  author={Anisa Mosam and Mahomed Aslam Sathar and Halima Dawood and Edana Cassol and Tonya Marianne Esterhuizen and Hoosen Mohamed Coovadia},
  journal={AIDS},
  year={2007},
  volume={21},
  pages={1377–1379}
}
In 38 African AIDS patients initiating generic HAART, GB virus C (GBV-C) RNA-positive patients retained GBV-C viraemia during 52 weeks of HAART, had a faster decline in HIV viral load (P = 0.03), fewer opportunistic infections (14.3 versus 50%, P = 0.18), and suffered no serious adverse events (none versus 61%, P = 0.008) compared with patients without GBV-C. GBV-C co-infection may be associated with a beneficial effect on African AIDS patients treated with generic HAART. 
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References

SHOWING 1-5 OF 5 REFERENCES
Effect of GB virus C on response to antiretroviral therapy in HIV‐infected Brazilians *
TLDR
To determine the effect of GBV‐C on ART, plasma samples taken from patients in a prospective randomized clinical trial of ART in HIV‐positive Brazilians were retrospectively analysed.
GB virus type C coinfection in HIV-infected African mothers and their infants, KwaZulu Natal, South Africa.
TLDR
It was not possible to demonstrate evidence of in utero or intrapartum transmission of HIV from mother-to-infant, but the immunological indices measured tend to suggest an association with protection and or delayed progression of HIV disease in GBV-C-infected mothers.
GB virus C replicates in primary T and B lymphocytes.
TLDR
GBV-C RNA in purified CD4(+) and CD8(+) T lymphocytes and CD19(+) B lymphocytes removed ex vivo from infected donors is identified and replicated in vitro in these PBMC subsets, suggesting that GBv-C is a panlymphotropic virus.
Cytokines and their receptors in cardiovascular diseases — role of gp130 signalling pathway in cardiac myocyte growth and maintenance
TLDR
Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI‐3 kinase pathways may be a newly discovered mechanism that regulates these events in association with cy toprotective effect in myocardial diseases.