Effect of Fructose on Body Weight in Controlled Feeding Trials

@article{Sievenpiper2012EffectOF,
  title={Effect of Fructose on Body Weight in Controlled Feeding Trials},
  author={John L. Sievenpiper and Russell J. de Souza and Arash Mirrahimi and Matthew E. Yu and Amanda J. Carleton and Joseph Beyene and Laura Chiavaroli and Marco Di Buono and Alexandra L Jenkins and Lawrence A Leiter and Tom Wolever and Cyril W. C. Kendall and David J A Jenkins},
  journal={Annals of Internal Medicine},
  year={2012},
  volume={156},
  pages={291 - 304}
}
BACKGROUND The contribution of fructose consumption in Western diets to overweight and obesity in populations remains uncertain. PURPOSE To review the effects of fructose on body weight in controlled feeding trials. DATA SOURCES MEDLINE, EMBASE, CINAHL, and the Cochrane Library (through 18 November 2011). STUDY SELECTION At least 3 reviewers identified controlled feeding trials lasting 7 or more days that compared the effect on body weight of free fructose and nonfructose carbohydrate in… Expand
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Highly Influential Citations
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Citation Type

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A systematic review and meta-analysis of prospective cohort studies found that total fructose intake was not associated with an increased risk of hypertension in 3 large prospective cohorts of U.S. men and women. Expand
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Isoenergetic substitution of fructose or HFCS for glucose or sucrose has no significant effect on most of the cardiometabolic markers investigated; however, some results were affected by residual between-study heterogeneity and studies with high or unclear risk of bias. Expand
Effect of Fructose on Established Lipid Targets: A Systematic Review and Meta-Analysis of Controlled Feeding Trials
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Fructose only had an adverse effect on established lipid targets when added to existing diets so as to provide excess calories (+21% to 35% energy) and when isocalorically exchanged for other carbohydrates, fructose had no adverse effects on blood lipids. Expand
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Whole, fresh fruit probably does not contribute to obesity and may have a place in the prevention and management of excess adiposity, and long-term observational studies suggest that habitually higher fruit intake is not associated with weight change, or is associated with modest protection against weight gain, over five or more years. Expand
Determining the Effect of Total Fructose-Containing Sugars and Food Sources of Fructose-Containing Sugars on Glycemic Control
The role of fructose-containing sugars in diabetes remains unclear. We undertook two systematic reviews and meta-analyses (SRMAs) of controlled trials: one to assess the ecological validity of… Expand
Effect of fructose and its epimers on postprandial carbohydrate metabolism: A systematic review and meta-analysis.
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Small doses of allulose and tagatose, but not fructose, lead to modest improvements on postprandial glucose and insulin regulation, with a need for long-term RCTs to confirm the sustainability of these improvements. Expand
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