Effect of Fructose on Body Weight in Controlled Feeding Trials
@article{Sievenpiper2012EffectOF, title={Effect of Fructose on Body Weight in Controlled Feeding Trials}, author={John L. Sievenpiper and Russell J. de Souza and Arash Mirrahimi and Matthew E. Yu and Amanda J. Carleton and Joseph Beyene and Laura Chiavaroli and Marco Di Buono and Alexandra L. Jenkins and Lawrence A Leiter and Tom Wolever and Cyril W C Kendall and David J A Jenkins}, journal={Annals of Internal Medicine}, year={2012}, volume={156}, pages={291 - 304} }
BACKGROUND
The contribution of fructose consumption in Western diets to overweight and obesity in populations remains uncertain.
PURPOSE
To review the effects of fructose on body weight in controlled feeding trials.
DATA SOURCES
MEDLINE, EMBASE, CINAHL, and the Cochrane Library (through 18 November 2011).
STUDY SELECTION
At least 3 reviewers identified controlled feeding trials lasting 7 or more days that compared the effect on body weight of free fructose and nonfructose carbohydrate in…
262 Citations
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Energy control and food source appear to mediate the effect of fructose-containing sugars on glycaemic control, and although most food sources of these sugars do not have a harmful effect in energy matched substitutions with other macronutrients, several food sources including sugars-sweetened beverages adding excess energy to diets have harmful effects.
Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: a systematic review and meta-analysis of diet-intervention trials.
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Short-term fructose consumption, in isocaloric exchange or in hypercaloric supplementation, promotes the development of hepatic insulin resistance in nondiabetic adults without affecting peripheral or muscle insulin sensitivity.
Total Fructose Intake and Risk of Hypertension: A Systematic Review and Meta-Analysis of Prospective Cohorts
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- 2014
A systematic review and meta-analysis of prospective cohort studies found that total fructose intake was not associated with an increased risk of hypertension in 3 large prospective cohorts of U.S. men and women.
Effect of fructose instead of glucose or sucrose on cardiometabolic markers: a systematic review and meta-analysis of isoenergetic intervention trials.
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Isoenergetic substitution of fructose or HFCS for glucose or sucrose has no significant effect on most of the cardiometabolic markers investigated; however, some results were affected by residual between-study heterogeneity and studies with high or unclear risk of bias.
Effect of Fructose on Established Lipid Targets: A Systematic Review and Meta-Analysis of Controlled Feeding Trials
- MedicineJournal of the American Heart Association
- 2015
Fructose only had an adverse effect on established lipid targets when added to existing diets so as to provide excess calories (+21% to 35% energy) and when isocalorically exchanged for other carbohydrates, fructose had no adverse effects on blood lipids.
The Effect of Normally Consumed Amounts of Sucrose or High Fructose Corn Syrup on Lipid Profiles, Body Composition and Related Parameters in Overweight/Obese Subjects
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Fructose when consumed as part of a eucaloric diet fructose—when given with glucose does not promote weight gain or an atherogenic lipid profile even when consumed at two to four times the level recently recommended by the AHA.
Impact of Whole, Fresh Fruit Consumption on Energy Intake and Adiposity: A Systematic Review
- MedicineFront. Nutr.
- 2019
Whole, fresh fruit probably does not contribute to obesity and may have a place in the prevention and management of excess adiposity, and long-term observational studies suggest that habitually higher fruit intake is not associated with weight change, or is associated with modest protection against weight gain, over five or more years.
Determining the Effect of Total Fructose-Containing Sugars and Food Sources of Fructose-Containing Sugars on Glycemic Control
- Chemistry
- 2016
Fructose-containing sugars from different food sources, especially fruits, did not adversely affect glycemic control and improved HbA1c in isocaloric exchange with other macronutrients, however, supplementing diets with excess energy from fructosecontaining sugars across different food Sources, impaired fasting glucose and insulin.
Effect of fructose and its epimers on postprandial carbohydrate metabolism: A systematic review and meta-analysis.
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