Effect of Food on the Pharmacokinetics of Clozapine Orally Disintegrating Tablet 12.5 mg

  title={Effect of Food on the Pharmacokinetics of Clozapine Orally Disintegrating Tablet 12.5 mg},
  author={Anthony R. Disanto and Gil Golden},
  journal={Clinical Drug Investigation},
AbstractBackground and objective: Food has reportedly not affected the systemic bioavailability of the atypical antipsychotic drug clozapine. However, searches of the medical literature could find no studies to support this food claim for any formulation of clozapine. The purpose of the current study was to assess the effect of food on the bioavailability and pharmacokinetics of clozapine orally disintegrating tablet (ODT) following single 12.5 mg doses in the healthy subjects in fasted and fed… 

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