Effect of Food and Food Composition on Alcohol Elimination Rates in Healthy Men and Women

  title={Effect of Food and Food Composition on Alcohol Elimination Rates in Healthy Men and Women},
  author={Vijay A. Ramchandani and Paul Yien Kwo and Ting-kai Li},
  journal={The Journal of Clinical Pharmacology},
Several studies have evaluated the effect of food on alcohol pharmacokinetics; however, most studies have used oral alcohol administration, which cannot separate the influence of food on absorption from its influence on alcohol elimination. Alcohol clamping uses intravenous alcohol and provides a direct measure of the alcohol elimination rate (AER). Two studies, using alcohol clamping at 50 mg%, were conducted to investigate the effect of food and food composition on AER (g/h) in healthymenand… 

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The same nine subjects were given near bolus doses of alcohol on two occasions separated by one week and instructed to consume the alcohol as rapidly as possible, finding the average elimination rate of ethanol was found to be significantly lower after meal.

Effect of high-fat, high-protein, and high-carbohydrate meals on the pharmacokinetics of a small dose of ethanol.

Drinking ethanol after eating a meal, regardless of the nutritional composition, decreases the systemic availability of ethanol.

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The influence of several factors on the blood alcohol course after drinking diluted ethanol was studied in young, healthy volunteers under strictly standardized conditions, with results indicating that sex, dose and concentration of the alcohol, physical exercise immediately after drinking, meal consumption before drinking and energy content and composition of the meal had an attenuating effect.

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  • H. Kalant
  • Medicine
    Alcoholism, clinical and experimental research
  • 2000
This chapter discusses the effects of food and body composition on the levels of blood alcohol, and the use of ‘area under the curve’ measurements to estimate oral bioavailability under conditions in which this method is not applicable.

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