Effect of Folic Acid and Vitamin B12 on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells

Abstract

Pemetrexed (MTA) is a multitargeted antifolate drug approved for lung cancer therapy. Clinically, supplementation with high doses of folic acid (FA) and vitamin B12 (VB12) lowers MTA cytotoxicities. An antagonistic effect of FA/VB12 on MTA efficacy has been proposed. However, patients who receive FA/VB12 show better tolerance to MTA with improved survival… (More)
DOI: 10.1155/2013/389046

Topics

7 Figures and Tables

Cite this paper

@inproceedings{Yang2013EffectOF, title={Effect of Folic Acid and Vitamin B12 on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells}, author={Tsung-Ying Yang and G. T. G. Chang and Shih-Lan Hsu and Yi-Rou Huang and Ling-Yen Chiu and Gwo-Tarng Sheu}, booktitle={BioMed research international}, year={2013} }