Effect of Fenugreek Seed and Leaves on Some Hematological and Biochemical Parameters in CCl4-induced Liver Injury

  title={Effect of Fenugreek Seed and Leaves on Some Hematological and Biochemical Parameters in CCl4-induced Liver Injury},
  author={Firdaws A. Al Mashhadani},
  journal={International Journal of Current Microbiology and Applied Sciences},
Medicinal plants are important part of health care. Large varieties of plants (more than 1200) are available with known therapeutic effects (Kipkore et al., 2014). Approximately 70–80% people worldwide depend on medicinal plants to cure various human ailments including viral diseases (Wang and Liu, 2013). Moreover, herbal drugs have gained much importance due to their easily adaptability, low cost and fewer side reactions on patients (Edziri et al., 2011). 
4 Citations
Curative and hepatoprotective action of fenugreek (Trigonellafoenumgaraecum) seeds against cisplatin induced oxidative liver damage in male albino rats
It can be concluded that fenugreek seed improved the activities of liver functions and antioxidant enzymes against cisplatin that induced oxidative liver injury in male albino rats. Expand
Nephroprotective Effect of Malva sylvestris Extract against CCl4 Induced Nephrotoxicity in Albino Rats
The aim of the study was to evaluate the potential effect of Malva sylvestris(M. sylvestris) extract on nephrotoxicity caused by CCl4 in rats. Forty rats were divided into four equal groups. Group 1:Expand
Effects of Trigonella foenum graecum L. seeds on liver structure, liver function biomarkers and some hematological and some physiological parameters in rats
It could be concluded that 2.5% Trigonella foenum graecum is safe to be used for 8 weeks without any adverse side effects on liver structure and functions and some physiological and hematological parameters in normal male albino rats. Expand
Effect of Fenugreek Seed and Leaves on Some Hematological and Biochemical Parameters in CCl4-induced Liver Injury
Herbal drugs have gained much importance due to their easily adaptability, low cost and fewer side reactions on patients (Edziri et al., 2011). Expand


Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin
This review provides the chemistry, pharmacology and future aspects of picroliv, ellagic acid and curcumin with focus on hepatoprotective properties, which may prove to be very useful in the treatment of hepatotoxicity induced by viral agents, toxic drugs and plant poisons. Expand
Antioxidant and hepatoprotective activities of Ocimum basilicum Linn. and Trigonella foenum-graecum Linn. against H2O2 and CCL4 induced hepatotoxicity in goat liver.
The extract of leaves of O. basilicum and T. foenum-graecum showed significant anti lipid peroxidation effects in vitro, besides exhibiting significant activity in superoxide radical and nitric oxide radical scavenging, indicating their potent antioxidant effects. Expand
A review study on analgesic applications of Iranian medicinal plants.
Different methods of testing pain, analgesic activity and possible compounds of medicinal plants and also the possible mechanisms actions of these plants are presented to provide scientific information that might be used for isolation of potentially active compounds from some of these medicinal plants in future. Expand
Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity
The study investigates the effect of aqueous extract of fenugreek seeds on lipid peroxidation and antioxidant status in experimental ethanol toxicity in rats and finds that activity of Ca2+ ATPase in brain was lowered and activities of superoxide dismutase, catalase and glutathione peroxidase were observed in liver and brain. Expand
Hydroalcohol extract of Trigonella foenum-graecum seed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats
HEF may be useful as an adjuvant with clinically effective antidiabetic drugs in the management of type-II diabetes and Histoarchitecture of liver and pancreas showed marked improvement. Expand
Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice
This study supports the use of these active phytochemicals against toxic liver injury, which may act by preventing lipid peroxidation, augmenting the antioxidant defense system or by regenerating the hepatocytes. Expand
Protective and Antioxidant Effects of Cynara Scolymus Leaves against Carbon Tetrachloride Toxicity in Rats.
Cynarascolymus (artichoke) plant has many natural antioxidants. Artichokeleaves extract have multiple pharmacological actions. This study was designed to explore the potential of dietary artichokeExpand
Antibacterial Activity of Fenugreek Seeds ( Trigonella foenum-graecum ) Crude Extracts Against a Rabbit Escherichia coli Isolate
Post-weaned rabbits are sensitive to digestive disorders, some of which may be aggravated by enteric bacteria such as Escherichia coli. Fenugreek (Trigonella foenum-graecum) is a medicinal plantExpand
Antioxidative Activity of Extracts from Fenugreek Seeds (Trigonella foenum-graecum)
Spices and herbs possess antioxidant activity and can be applied for preservation of lipid peroxidation in biological systems. Fenugreek (Trigonella foenum-graecum) is an important spice; its driedExpand
Aqueous extract of Trigonella foenum graecum (fenugreek) prevents cypermethrin-induced hepatotoxicity and nephrotoxicity
Investigating the protective effect of aqueous extract of germinated fenugreek seeds in CM-induced hepatic and renal toxicity found it to play an important role in ameliorating the pesticide-induced toxicity. Expand