Effect of FSH receptor-binding inhibitor-8 on FSH-mediated granulosa cell signaling and proliferation.

@article{Navalakhe2013EffectOF,
  title={Effect of FSH receptor-binding inhibitor-8 on FSH-mediated granulosa cell signaling and proliferation.},
  author={Rajshri M Navalakhe and Dhanashree D. Jagtap and Sumeet U Nayak and Tarala D. Nandedkar and Smita D. Mahale},
  journal={Chemical biology & drug design},
  year={2013},
  volume={82 2},
  pages={178-88}
}
Follicle-stimulating hormone is important for mammalian reproduction. It acts through specific receptors located on the plasma membrane of granulosa cells in ovaries and Sertoli cells in testes. The binding of follicle-stimulating hormone to its receptor activates intracytoplasmic signaling pathways leading to steroidogenesis. These steroids in turn regulate the follicle-stimulating hormone action from the anterior pituitary through exerting negative feedback effect. In addition to steroids… CONTINUE READING
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