Effect of FK506 in reducing scar formation by inducing fibroblast apoptosis after sciatic nerve injury in rats

@inproceedings{Que2013EffectOF,
  title={Effect of FK506 in reducing scar formation by inducing fibroblast apoptosis after sciatic nerve injury in rats},
  author={Jun Que and Qin-hong Cao and Tao Sui and Si-dan Du and Delong Kong and Xinyuan Cao},
  booktitle={Cell Death and Disease},
  year={2013}
}
We previously demonstrated that FK506, a generally applied immunosuppressant in organ transplantation, could promote peripheral nerve regeneration through reducing scar formation. However, little is known about how FK506 reduces scar formation. Herein we investigated the influence of FK506 on fibroblast proliferation and its correlation with scar formation after sciatic nerve injury in rats, and further explored the effect of FK506 on fibroblast proliferation and apoptosis in vitro. Masson… CONTINUE READING
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