Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo.

@article{Kadowaki1993EffectOF,
  title={Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo.},
  author={Makoto Kadowaki and Yukinori Nagakura and Masaaki Nishi-Iwata Tomoi and Junichi Mori and Masanobu Kohsaka},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={266 1},
  pages={
          74-80
        }
}
5-Hydroxytryptamine (5-HT) is an important neurotransmitter and hormone/paracrine agent mediating various enteric functions. Its precise physiological and pathophysiological role remains unclear. This study investigated the effects of 5-HT on colonic function and the effects of the newly developed 5-HT3 and 5-HT4 receptor antagonist, FK1052, on colonic responses to 5-HT or stress stimulus in vivo. In conscious rats, both 5-HT and 5-methoxytryptamine significantly increased fecal pellet output… CONTINUE READING

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