Effect of FCGR2A and FCGR3A variants on CLL outcome.

  title={Effect of FCGR2A and FCGR3A variants on CLL outcome.},
  author={David Dornan and Olivia Spleiss and Ru-Fang Yeh and Guillemette Duchateau-Nguyen and Annika Dufour and Jianguo Zhi and Tadeusz Robak and Sergey I. Moiseev and Anna Dmoszyńska and Philippe Solal-C{\'e}ligny and Krzysztof Warzocha and Javier Loscertales and John Vincent Catalano and Boris V. Afanasiev and Loree M. Larratt and Viktor A. Rossiev and Isabelle Bence-Bruckler and Christian Hartmann Geisler and Marco Montillo and Michael Wenger and Martin Weisser},
  volume={116 20},
Polymorphisms of activating Fc-γ receptors (FCGRs) on natural killer cells and macrophages result in variable affinity for immunoglobulin G1 monoclonal antibodies and subsequently modulate antibody-dependent cellular cytotoxicity (ADCC) activity. Whether single-nucleotide polymorphisms of FCGRs correlate with survival of chronic lymphocytic leukemia (CLL) patients treated with a monoclonal antibody containing regimen is unclear. We assessed the FCGR3A and FCGR2A genotype of patients enrolled in… CONTINUE READING


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