Effect of F8 B domain gene variants on synthesis, secretion, activity and stability of factor VIII protein.

Abstract

The B domain of the coagulation factor (F)VIII comprises some unique characteristics. Though the B domain is important for processing, intracellular transport and secretion of FVIII protein, its role in the coagulation still remains unclear. This study aims to investigate the influence of 19 reported B domain variants on quantity and quality of expressed… (More)
DOI: 10.1160/TH13-01-0028

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Cite this paper

@article{Pahl2014EffectOF, title={Effect of F8 B domain gene variants on synthesis, secretion, activity and stability of factor VIII protein.}, author={Saskia Pahl and A. I. Pavlova and J. J. M. Driesen and Johannes Oldenburg}, journal={Thrombosis and haemostasis}, year={2014}, volume={111 1}, pages={58-66} }