Effect of Exogenous and Endogenous Nitric Oxide on the Airway and Tissue Components of Lung Resistance in the Newborn Piglet

@article{Potter1997EffectOE,
  title={Effect of Exogenous and Endogenous Nitric Oxide on the Airway and Tissue Components of Lung Resistance in the Newborn Piglet},
  author={Charles F Potter and Ismail A. Dreshaj and Musa A. Haxhiu and Eileen K Stork and Robert L. Chatburn and Richard J. Martin},
  journal={Pediatric Research},
  year={1997},
  volume={41},
  pages={886-891}
}
Despite widespread reports of the vasodilatory actions of nitric oxide(NO), little is known of the relaxant effect of NO on newborn airways or lung parenchymal structures. We studied the effects of inhaled NO at 20, 40, and 80 ppm on lung (Rl), tissue (Rti), and airway (Raw) resistance in 13 2-5-d-old anesthetized, ventilated, open-chested piglets. Rl was measured from transpulmonary pressure and air flow. Rti was measured by alveolar capsules, and Raw was calculated as the difference between… CONTINUE READING

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