Effect of Epstein-Barr virus infection on response to chemotherapy and survival in Hodgkin's disease.

@article{Murray1999EffectOE,
  title={Effect of Epstein-Barr virus infection on response to chemotherapy and survival in Hodgkin's disease.},
  author={Paul Gerard Murray and Lucinda Jane Billingham and H. T. Hassan and Joanne R Flavell and Paul N Nelson and Kathryn Scott and George Reynolds and Christothea M. Constandinou and David James Kerr and E C Devey and John Crocker and Lawrence S Young},
  journal={Blood},
  year={1999},
  volume={94 2},
  pages={442-7}
}
We have analyzed paraffin sections from 190 patients with histologically confirmed Hodgkin's disease (HD) for the presence of Epstein-Barr virus (EBV) using in situ hybridization to detect the EBV-encoded Epstein-Barr virus early RNAs (EBERs) and immunohistochemistry to identify latent membrane protein-1 (LMP1) expression. EBV was present in the tumor cells in 51 HD cases (27%) and was mainly confined to the mixed cellularity and nodular sclerosis subtypes. There was no difference between EBV… CONTINUE READING
Highly Cited
This paper has 47 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Ambinder RF:bcl-2 but not the EBV-encoded bcl-2 homologue, BHRF1, is commonly expressed in post-transplantation lymphoproliferative disorders

PG Murray, LJ Swinnen, +3 authors JM Hardwick
Blood 87:706, • 1996
View 1 Excerpt

Similar Papers

Loading similar papers…