Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder

@article{Wade2016EffectOE,
  title={Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder},
  author={Benjamin S. C. Wade and Shantanu H. Joshi and Stephanie Njau and Amber M. Leaver and Megha M Vasavada and Roger P. Woods and Boris A. Gutman and Paul M. Thompson and Randall T Espinoza and Katherine Narr},
  journal={Neuropsychopharmacology},
  year={2016},
  volume={41},
  pages={2481-2491}
}
Patients with major depression show reductions in striatal and paleostriatal volumes. The functional integrity and connectivity of these regions are also shown to change with antidepressant response. Electroconvulsive therapy (ECT) is a robust and rapidly acting treatment for severe depression. However, whether morphological changes in the dorsal and ventral striatum/pallidum relate to or predict therapeutic response to ECT is unknown. Using structural MRI, we assessed cross-sectional effects… CONTINUE READING
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