Effect of Diethylcarbamazine Citrate and Setaria equina Excretory–Secretory Material on Rat Hepatocellular Carcinoma

@article{AbdelLatif2014EffectOD,
  title={Effect of Diethylcarbamazine Citrate and Setaria equina Excretory–Secretory Material on Rat Hepatocellular Carcinoma},
  author={Mahmoud Abdel-Latif and Thabet Farrag Sakran and Gamal El-Shahawi and Hoda El-Fayoumi and Al-Mahy El-Mallah},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
  year={2014},
  volume={62},
  pages={511-520}
}
Diethylcarbamazine citrate (DEC) has been known for its efficacy to eradicate bancroftian filariasis in Egypt and other countries in the world. One of the known effects was to decrease the level of circulating filarial antigen in the patient’s serum. The target of this study was to examine the effect of DEC, excretory–secretory (ES) material from the filarial parasite Setaria equina or a combination of both on the status of oxidative stress and pathogenesis of rat hepatocellular carcinoma (HCC… 
Identification of the complement 9‐binding protein in Setaria equina excretory‐secretory products
TLDR
S equina OV‐16 is the complement regulatory protein by its ability to bind C9 and inhibit the classical and alternative pathways of complement activation.
Detection for cross-reactive proteins in filarial worm Setaria equina, MCF-7 human breast cancer, and Huh-7 hepatoma cells
TLDR
The results indicated cross-reactive bands at 70 and 75 kDa in all extracts by anti-DEC and SeqE antibodies, respectively, and the expression of 70 kDa protein was only reduced in filarial worms and Huh-7 after in vitro DEC treatment compared to the control.

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