Effect of Diethylcarbamazine Citrate and Setaria equina Excretory–Secretory Material on Rat Hepatocellular Carcinoma

  title={Effect of Diethylcarbamazine Citrate and Setaria equina Excretory–Secretory Material on Rat Hepatocellular Carcinoma},
  author={Mahmoud Abdel-Latif and Thabet Farrag Sakran and Gamal El-Shahawi and Hoda El-Fayoumi and Al-Mahy El-Mallah},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
Diethylcarbamazine citrate (DEC) has been known for its efficacy to eradicate bancroftian filariasis in Egypt and other countries in the world. One of the known effects was to decrease the level of circulating filarial antigen in the patient’s serum. The target of this study was to examine the effect of DEC, excretory–secretory (ES) material from the filarial parasite Setaria equina or a combination of both on the status of oxidative stress and pathogenesis of rat hepatocellular carcinoma (HCC… 
Identification of the complement 9‐binding protein in Setaria equina excretory‐secretory products
S equina OV‐16 is the complement regulatory protein by its ability to bind C9 and inhibit the classical and alternative pathways of complement activation.
Detection for cross-reactive proteins in filarial worm Setaria equina, MCF-7 human breast cancer, and Huh-7 hepatoma cells
The results indicated cross-reactive bands at 70 and 75 kDa in all extracts by anti-DEC and SeqE antibodies, respectively, and the expression of 70 kDa protein was only reduced in filarial worms and Huh-7 after in vitro DEC treatment compared to the control.


Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug
The evidence for an indirect mode of action for one major anti-filarial drug, diethylcarbamazine (DEC), is discussed, and the interpretation most consistent with existing data is that DEC alters arachidonic acid metabolism in microfilariae and in host endothelial cells.
Alterations in filarial antigen-specific immunologic reactivity following treatment with ivermectin and diethylcarbamazine.
Results provide additional evidence that microfilariae modulate antifilarial immune reactivity and reduce microfilaremia levels in a Haitian population treated with diethylcarbamazine and ivermectin.
Macrofilaricidal activity of metabolites of diethylcarbamazine.
In the rodent and in man, the antifilarial action of DEC is swift and of short duration, but in some human filariasis i.e. loaiasis, lymphatic filARIasis, the spectrum of DEC activities extends to adult filaria.
Lymphatic filariasis: possible pathophysiological nexus with oxidative stress.
Analysis and potential of excretory-secretory antigens of Setaria cervi for immunodiagnosis of human filariasis.
The excretory-secretory (E-LS) products released by the adult Setaria cervi were used to raise polyvalent hyperimmune serum in rabbits and the anti-E-S antibodies could detect circulating antigen in filarial patients sera by Counter immunoelectrophoresis.
Diethylcarbamazine: effect on lysosomal enzymes and acetylcholine in Wuchereria bancrofti infection
We measured the levels of lysosomal enzymes and acetylcholine in Wuchereria bancrofti– infected asymptomatic microfilaraemic human serum, and found a significant decrease in the activity of
Resistance of filarial nematode parasites to oxidative stress.
Effect of diethylcarbamazine on chronic hepatic inflammation induced by alcohol in C57BL/6 mice.