Effect of Dextrometorphan and Dextrorphan on Nicotine and Neuronal Nicotinic Receptors: In Vitro and in Vivo Selectivity

@article{Damaj2005EffectOD,
  title={Effect of Dextrometorphan and Dextrorphan on Nicotine and Neuronal Nicotinic Receptors: In Vitro and in Vivo Selectivity},
  author={Mohamad Imad Damaj and Pamela Dru Flood and Kenny K Ho and Everette L. May and Billy R. Martin},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={312},
  pages={780 - 785}
}
  • M. Damaj, P. Flood, +2 authors B. Martin
  • Published 1 February 2005
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
The effects of dextrometorphan and its metabolite dextrorphan on nicotine-induced antinociception in two acute thermal pain assays after systematic administration were evaluated in mice and compared with that of mecamylamine. Dextrometorphan and dextrorphan were found to block nicotine's antinociception in the tail-flick and hot-plate tests with different potencies (dextrometorphan is 10 times more potent than its metabolite). This blockade was not due to antagonism of N-methyl-d-aspartate… 
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