Effect of Dehydroepiandrosterone on Muscle Strength and Physical Function in Older Adults: A Systematic Review

@article{Baker2011EffectOD,
  title={Effect of Dehydroepiandrosterone on Muscle Strength and Physical Function in Older Adults: A Systematic Review},
  author={William L. Baker and Shobha Karan and Anne Kenny},
  journal={Journal of the American Geriatrics Society},
  year={2011},
  volume={59}
}
OBJECTIVES: To evaluate studies that have assessed the effect of dehydroepiandrosterone (DHEA) supplementation on body composition and physical performance in older adults. 

Sex hormones and sarcopenia in older persons

DHEAS and testosterone are important options in the armamentarium of sarcopenia treatment in older men, and future studies are needed to address new approaches by using selective compounds, targeting the correct form and dosage, tailoring the correct patient to treat, and taking into account the multifactorial origin.

OPINION Sex hormones and sarcopenia in older persons

DHEAS and testosterone are important options in the armamentarium of sarcopenia treatment in older men and future studies are needed to address new approaches by using selective compounds, targeting the correct form and dosage, tailoring the correct patient to treat, and taking into account the multifactorial origin.

Pharmacological Interventions to Improve Muscle Mass, Muscle Strength and Physical Performance in Older People: An Umbrella Review of Systematic Reviews and Meta-analyses

Only vitamin D, especially in older women, and testosterone in older men with clinical muscle weakness and low testosterone serum levels can be justified in daily clinical practice to improve muscle mass, muscle strength and/or physical performance.

Hormones and sarcopenia

[Effect of muscle strength training on urinary incontinence and physical function: a randomized controlled trial in long-term care facilities].

Whether muscle strength training programs have an impact on improving symptoms of urinary incontinence and physical function among elderly women with UI who reside in long-term care facilities is investigated.

Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons.

The need of future synergistic optional treatments to improve the effectiveness of hormonal treatment and to safely ameliorate the anabolic hormonal status and mobility in older individuals is underlined.

Current Status of Sarcopenia in Korea: A Focus on Korean Geripausal Women

  • H. Park
  • Medicine, Biology
    Annals of geriatric medicine and research
  • 2018
Sarcopenia, osteoporosis, and obesity share several pathophysiological mechanisms, and a combination of these entities may lead to an increased risk of musculoskeletal, cardio-metabolic, and psychological morbidities especially in geripause populations.

Association of androgen with skeletal muscle mass and muscle function among men and women aged 50 years and older in Taiwan: results from the I-Lan longitudinal aging study.

The free androgen index increased remarkably along with muscle mass and muscle strength among men and women aged 50 years and older in Taiwan and was also associated with aging and gait speed in both genders.

Comprehensive approach to sarcopenia treatment.

Although there are some intriguing pharmaceutical therapies to combat sarcopenia, resistance training combined with supplements containing amino acids are the most effective for preventing and treating age-related muscle wasting and weakness.
...

References

SHOWING 1-10 OF 36 REFERENCES

Dehydroepiandrosterone Combined with Exercise Improves Muscle Strength and Physical Function in Frail Older Women

OBJECTIVES: To investigate the effects of dehydroepiandrosterone (DHEA) combined with exercise on bone mass, strength, and physical function in older, frail women.

Association of Dehydroepiandrosterone Sulfate, Body Composition, and Physical Fitness in Independent Community‐Dwelling Older Men and Women

OBJECTIVES: To determine the association of dehydroepiandrosterone sulfate (DHEAS), body composition, and physical fitness in independent community‐dwelling men and women aged 60 to 80 years.

Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women.

Twelve weeks of combined endurance and resistance training significantly improved body composition, physical performance, insulin sensitivity, and low-density lipoprotein cholesterol particle number and size, whereas DHEA had no additional benefits.

Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial.

DHEA replacement therapy for 1 yr improved hip BMD in older adults and spine B MD in older women and the need for further investigations of the benefits and risks of D HEA replacement and the mechanisms for its actions is supported.

Supplementation with DHEA: effect on muscle size, strength, quality of life, and lipids.

Androgen replacement therapy, with DHEA, to menopausal women increases serum androgen levels without any appreciable effect on muscle cross-sectional area, muscle strength, muscle function, or improvement in health-related QOL.

DHEA enhances effects of weight training on muscle mass and strength in elderly women and men.

Evidence is provided that DHEA replacement has the beneficial effect of enhancing the increases in muscle mass and strength induced by heavy resistance exercise in elderly individuals.

Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial

Among older healthy adults, daily administration of 50 mg of DHEA has a modest and selective beneficial effect on BMD and bone resorption in women, but provides no bone benefit for men.

Effects of dehydroepiandrosterone (DHEA) on cardiovascular risk factors in older women with frailty characteristics.

Investigation of the effects of dehydroepiandrosterone (DHEA) on cardiovascular risk factors in older women with frailty characteristics adds to the literature that short-term therapy with DHEA is safe for older women in relation to cardiovascular risk Factors.

Effects of dehydroepiandrosterone and atamestane supplementation on frailty in elderly men.

The results of this double-blind, randomized trial do not support the hypothesis that hormone replacement with DHEA and/or atamestane might improve the course of frailty.

Sarcopenia: origins and clinical relevance.

This presentation reflects on the origins of the term sarcopenia. The Greek roots of the word are sarx for flesh and penia for loss. The term actually describes important changes in body composition