Effect of Database Size in the Genetic Variants Calling

@inproceedings{Kim2019EffectOD,
  title={Effect of Database Size in the Genetic Variants Calling},
  author={Sunhee Kim and Young-suk Lee and Chang-Yong Lee},
  booktitle={BIOINFORMATICS},
  year={2019}
}
The base quality score recalibration (BQSR) is an important step in the variant calling from high-throughput sequence data. Motivated by the fact that BQSR necessarily requires a database of known variants such as the dbSNP, we present an extensive analysis on BQSR results for human and rice genome. We showed that the recalibration results depended on the size of the database: the more variants are there in the database, the larger averaged value of the recalibrated base quality scores is… 

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