Effect of Dapagliflozin on Clinical Outcomes in Patients with Chronic Kidney Disease, With and Without Cardiovascular Disease.

@article{McMurray2020EffectOD,
  title={Effect of Dapagliflozin on Clinical Outcomes in Patients with Chronic Kidney Disease, With and Without Cardiovascular Disease.},
  author={John J. V. McMurray and David C. Wheeler and Bergur V Stefansson and Niels Jongs and Douwe Postmus and Ricardo Correa-Rotter and Glenn M. Chertow and Tom Greene and Claes Held and Fan-fan Hou and Johannes F E Mann and Peter Rossing and Carl David Sj{\"o}str{\"o}m and Robert D. Toto and Anna Maria Langkilde and Hiddo J Lambers Heerspink},
  journal={Circulation},
  year={2020}
}
Background: Dapagliflozin reduces the risk of end-stage renal disease in patients with chronic kidney disease. We examined the relative risk of cardiovascular and kidney events in these patients and the effect of dapagliflozin on either type of event, taking account of history of cardiovascular disease. Methods: In the DAPA-CKD trial (Dapagliflozin And Prevention of Adverse Outcomes in Chronic Kidney Disease), 4304 participants with chronic kidney disease were randomized to dapagliflozin 10 mg… Expand

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