Effect of DTNB light chain on the interaction of vertebrate skeletal myosin with actin

@article{Margossian1975EffectOD,
  title={Effect of DTNB light chain on the interaction of vertebrate skeletal myosin with actin},
  author={Sarkis S. Margossian and Susan Lowey and Bruce A Barshop},
  journal={Nature},
  year={1975},
  volume={258},
  pages={163-166}
}
MYOSIN from vertebrate skeletal muscles contains four low molecular weight subunits which are thought to play a functional role in the enzymic activity of myosin1,2 Removal of ‘alkali light chains’ (21,000 and 17,000 g mol−1) results in complete loss of ATPase activity, but dissociation of ‘DTNB light chain’ (18,000 g mol−1) leaves the enzymic activity of myosin essentially unaffected3–6. Since harsh solvents are required to dissociate alkali light chains from heavy chains (as the name implies… CONTINUE READING

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