Effect of DNA damage response by quinazolinone analogue HMJ-38 on human umbilical vein endothelial cells

@article{Chiang2014EffectOD,
  title={Effect of DNA damage response by quinazolinone analogue HMJ-38 on human umbilical vein endothelial cells},
  author={Jo-Hua Chiang and J. Yang and C-C Lu and M-J Hour and K-C Liu and J. Lin and T-H Lee and J. Chung},
  journal={Human & Experimental Toxicology},
  year={2014},
  volume={33},
  pages={590 - 601}
}
The present study aims to explore the mechanism of quinazolinone analogue HMJ-38-induced DNA damage in endothelial cells in vitro. We attempt to evaluate the antiangiogenetic response utilizing human umbilical vein endothelial cells (HUVECs). Herein, the results demonstrated that HMJ-38 incubation triggered DNA damage behavior and showed a longer DNA migration in HUVECs based on the comet assay and the analysis of DNA agarose gel electrophoresis to contact DNA smears. We further gained to… Expand
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