Effect of DNA-binding drugs on early growth response factor-1 and TATA box-binding protein complex formation with the herpes simplex virus latency promoter.

@article{Chiang1996EffectOD,
  title={Effect of DNA-binding drugs on early growth response factor-1 and TATA box-binding protein complex formation with the herpes simplex virus latency promoter.},
  author={Sheng W Chiang and J J Welch and F. Rauscher and Terry A. Beerman},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 39},
  pages={23999-4004}
}
Adjacent binding sites for early growth response factor-1 (EGR1) and TATA box-binding protein (TBP) were identified on the herpes simplex virus latency promoter in previous work. The binding of EGR1 to the GC-rich region prevented TBP binding to the AT-rich region. With the simultaneous addition of both EGR1 and TBP, the intercalator nogalamycin prevented EGR1 complex formation, resulting in a dose-dependent increase of the TBP.DNA complex. The minor groove binder chromomycin A3 inhibited EGR1… CONTINUE READING

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With the simultaneous addition of both EGR1 and TBP , the intercalator nogalamycin prevented EGR1 complex formation , resulting in a dose - dependent increase of the TBP.DNA complex .
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