Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells.

@article{Bannon2003EffectOD,
  title={Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells.},
  author={Desmond I. Bannon and Roger Abounader and Peter S. J. Lees and Joseph P. Bressler},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={284 1},
  pages={C44-50}
}
DMT1 (divalent metal transporter 1) is a hydrogen-coupled divalent metal transporter with a substrate preference for iron, although the protein when expressed in frog oocytes transports a broad range of metals, including the toxic metals cadmium and lead. Wild-type Caco-2 cells displayed saturable transport of lead and iron that was stimulated by acid. Cadmium and manganese inhibited transport of iron, but zinc and lead did not. The involvement of DMT1 in the transport of toxic metals was… CONTINUE READING

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