Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task

  title={Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task},
  author={Nikolaos Pitsikas and Alessandro Brambilla and Franco Borsini},
  journal={Pharmacology Biochemistry and Behavior},

Effects of serotonin 5-HT2A/2C antagonists on associative learning in the rabbit

The ability of ritanserin and MDL-11,939 to produce effects on learning and performance that were opposite to that of 5-HT2A/2C agonists suggests that they may be acting as inverse agonists at that receptor.

Different Effects of Tropisetron and Ondansetron in Learning and Memory Paradigms

Serotonergic drug effects on a delayed conditional discrimination task in the rat; involvement of the 5-HT1A receptor in working memory

It is suggested that the role of central serotonin receptors in WM may be restricted to 5-HT1A receptors.

Role of the serotonin 5-HT(2A) receptor in learning.

  • J. Harvey
  • Psychology, Biology
    Learning & memory
  • 2003
It was concluded that the 5-HT2A receptor demonstrates constitutive activity, and that variations in this activity can produce profound alterations in cognitive states.

Effects of Glucose on Scopolamine-Induced Learning Deficits in Rats Performing the Morris Water Maze Task

The results may suggest that the effect of glucose changes as a function of the degree of learning of the spatial learning task as well as the possibility of task specificity of the glucose effect.



Ondansetron and arecoline prevent scopolamine-induced cognitive deficits in the marmoset

The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates

The 5-HT3 receptor antagonists ICS 205-930 and GR38032F, putative anxiolytic drugs, differ from diazepam in their pharmacological profile

The results suggest that the 5-HT3 receptor antagonists may represent a new class of anxiolytic drugs devoid of anticonvulsant, sedative or muscle-relaxant properties, and that their anxi olytic activity is not mediated by benzodiazepine receptors.

5‐HT1A agonists increase and 5‐HT3 agonists decrease acetylcholine efflux from the cerebral cortex of freely‐moving guinea‐pigs

The results suggest that exogenous 5‐ HT and related selective agonists modulate guinea‐pig cortical cholinergic structures through 5‐HT1A and5‐HT3 receptors through 4‐Iodo‐2,5‐dimethoxyphenyl)2‐aminopropane and 8‐OH‐DPAT.