Effect of D240G substitution in a novel ESBL CTX-M-27.

@article{Bonnet2003EffectOD,
  title={Effect of D240G substitution in a novel ESBL CTX-M-27.},
  author={R. Bonnet and Christine Recule and Regine Baraduc and Corinne Chanal and Danielle Sirot and Christophe de Champs and Joel Sirot},
  journal={The Journal of antimicrobial chemotherapy},
  year={2003},
  volume={52 1},
  pages={29-35}
}
Escherichia coli clinical strain Gre-1 collected in 2000 from a French hospital harboured a novel CTX-M-encoding gene, designated blaCTX-M-27. CTX-M-27 differed from CTX-M-14 only by the substitution D240G and was the third CTX-M enzyme harbouring this mutation after CTX-M-15 and CTX-M-16. The Gly-240-harbouring enzyme CTX-M-27 conferred to E. coli higher MICs of ceftazidime (MIC, 8 versus 1 mg/L) than did the Asp-240-harbouring CTX-M-14 enzyme. Comparison of CTX-M-14 and CTX-M-27 showed that… CONTINUE READING

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