Effect of D-cycloserine on rapid tolerance to ethanol.

@article{Khanna1993EffectOD,
  title={Effect of D-cycloserine on rapid tolerance to ethanol.},
  author={Jatinder M. Khanna and Harold Kalant and Gaurang Shah and Amanda Chau},
  journal={Pharmacology, biochemistry, and behavior},
  year={1993},
  volume={45 4},
  pages={983-6}
}
We recently reported that the noncompetitive NMDA antagonists, (+)MK-801 and ketamine, block the development of rapid tolerance to ethanol. In the present article, we show that D-cycloserine (CS), an agonist at the glycine site of the NMDA receptor that enhances learning and memory, also enhances the development of rapid tolerance to ethanol. Rats were pretreated on day 1 with saline or CS, followed 30 min later by ethanol (2.3 g/kg, IP) or saline. At the end of motor impairment testing on the… CONTINUE READING
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