Effect of Cyclooxygenase-2 Inhibition on Renal Function in Elderly Persons Receiving a Low-Salt Diet

@article{Swan2000EffectOC,
  title={Effect of Cyclooxygenase-2 Inhibition on Renal Function in Elderly Persons Receiving a Low-Salt Diet},
  author={S. Swan and D. Rudy and K. Lasseter and C. F. Ryan and K. Buechel and L. Lambrecht and M. B. Pinto and S. Dilzer and O. Obrda and K. Sundblad and C. Gumbs and D. Ebel and H. Quan and P. Larson and J. Schwartz and T. Musliner and B. Gertz and D. Brater and S. Yao},
  journal={Annals of Internal Medicine},
  year={2000},
  volume={133},
  pages={1-9}
}
The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) are mediated through their ability to inhibit cyclooxygenase (COX)-catalyzed prostaglandin production. Two isoforms of COX, COX-1 and COX-2, have been identified (1-4); traditional NSAIDs inhibit both isoforms (5). Cyclooxygenase-1 is constitutively expressed throughout the body and is thought to play an essential role in normal gastrointestinal and platelet function, whereas COX-2 is induced in the presence of inflammation… Expand
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