Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study

@article{Hejazi2016EffectOC,
  title={Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study},
  author={Jalal Hejazi and Reza Rastmanesh and Forough Azam Taleban and Seyed Hadi Molana and Ehsan Hejazi and Golamreza Ehtejab and Noboru Hara},
  journal={Nutrition and Cancer},
  year={2016},
  volume={68},
  pages={77 - 85}
}
Curcumin is an antioxidant agent with both radiosensitizing and radioprotective properties. [...] Key Method Forty patients treated with radiotherapy for prostate cancer were randomized to the curcumin (CG, n = 20) or placebo group (PG, n = 20). They received curcumin (total 3 g/day) or placebo during external-beam radiation therapy of up to 74 Gy.Expand
Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials
TLDR
Subgroup analyses displayed that curcumin could significantly reduce MDA levels with or without use of piperine, however it could increase SOD level in presence of pipersine, which suggest thatCurcumin may be used as an adjunct therapy in individuals with oxidative stress. Expand
Experimental and clinical studies on radiation and curcumin in human glioma
TLDR
No interaction was found on the survival of U251 human glioma cells after irradiation in combination with curcumin at clinically achievable concentrations, and reported GBM intratumouralCurcumin concentrations are too low to either exert an own cytotoxic effect or to synergistically interact with radiation. Expand
Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer
TLDR
Intensity modulated radiotherapy combined with endocrinotherapy was safe and well tolerated in the treatment of middle and advanced prostate cancer and can improve the short-term efficacy and effectively reduce the serum oncological index concentration of patients. Expand
Curcumin for the Treatment of Prostate Diseases: A Systematic Review of Controlled Clinical Trials.
TLDR
It is demonstrated that turmeric or curcumin supplementation might have beneficial effects on some parameters related to prostate diseases, but it should be noted that some studies showed no effect. Expand
An update of research evidence on nutrition and prostate cancer.
TLDR
The potential for a role of dietary intake for the prevention and treatment of PCa remains promising and maintaining a healthy body weight and following a healthy dietary pattern including antioxidant rich fruits and vegetables, reduced animal fat and refined carbohydrates, should be encouraged. Expand
Is Curcumin the Answer to Future Chemotherapy Cocktail?
TLDR
Curcumin combination treatments were found to enhance anticancer effects, mediated by the multitargeting of several signalling pathways by curcumin and the co-administered cancer therapies. Expand
Role of turmeric extract in minimising mucositis in patients receiving radiotherapy for head and neck squamous cell cancer: a randomised, placebo-controlled trial
TLDR
Turmeric extract reduces the incidence and severity of radiation-induced mucositis, which can benefit patients undergoing radiation for head and neck cancer. Expand
Radiosensitizing Potential of Curcumin in Different Cancer Models
  • K. Sak
  • Medicine
  • Nutrition and cancer
  • 2019
TLDR
Radioensitizing effects of curcumin, a yellow-colored polyphenolic constituent of turmeric, in various preclinical cancer models, are presented and it is considered a promising adjuvant agent to enhance radiotherapeutic efficacy in the treatment of various cancer types formed in different human organ systems. Expand
Curcumin: A new candidate for melanoma therapy?
Melanoma remains among the most lethal cancers and, in spite of great attempts that have been made to increase the life span of patients with metastatic disease, durable and complete remissions areExpand
Growth and Proliferation of Renal Cell Carcinoma Cells Is Blocked by Low Curcumin Concentrations Combined with Visible Light Irradiation
TLDR
The present findings substantiate the potential of combining low curcumin concentrations and light as a new therapeutic concept to increase the efficacy ofCurcumin in RCC and confirm the anti-cancer properties of this substance in vitro. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
A Pilot Clinical Trial of Radioprotective Effects of Curcumin Supplementation in Patients with Prostate Cancer
TLDR
Curcumin can confer radioprotective effect in patients with prostate cancer who undergo radiation therapy through reducing the severity of radiotherapy related urinary symptoms, however supplementation with 3 g/ day curcumin could not reduce the severityof bowel symptoms or other treatment related symptoms. Expand
Oxidative Stress Markers in Prostate Cancer Patients after HDR Brachytherapy Combined with External Beam Radiation
TLDR
The results confirm that in the course of PCa, imbalance of oxidant-antioxidant processes occurs, and therapy did not alter the levels of oxidative stress markers, which may prove its applicability. Expand
Human plasma antioxidant capacity during radiotherapy for lung cancer: a clinical study.
TLDR
Changes in the human plasma total peroxyl radical trapping capacity (TRAP) and its individual components were followed during clinical radiotherapy for lung cancer to hypothesis was that oxygen-free radical production increased by irradiation should decrease the plasma TRAP as a consequence of oxidative stress. Expand
Curcumin for Radiation Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Thirty Breast Cancer Patients
TLDR
Oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients, and was associated with a reduction in RDS at end of treatment. Expand
Do Antioxidants Interfere With Radiation Therapy for Cancer?
  • R. Moss
  • Medicine
  • Integrative cancer therapies
  • 2007
TLDR
The preponderance of evidence supports a provisional conclusion that dietary antioxidants do not conflict with the use of radiotherapy in the treatment of a wide variety of cancers and may significantly mitigate the adverse effects of that treatment. Expand
The antioxidant status of patients subjected to total body irradiation.
TLDR
TBI caused a pronounced decrease in antioxidant capacity and an excessive increase in oxidant stress, and to a reconsideration of the routine use of Allopurinol as pretreatment for TBI, and antioxidant support before and/or after TBI. Expand
Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1.
TLDR
Since the 1970s, 280 peer-reviewed in vitro and in vivo studies, including 50 human studies involving 8,521 patients, 5,081 of whom were given nutrients, have consistently shown that non-prescription antioxidants and other nutrients do not interfere with therapeutic modalities for cancer. Expand
Effect of curcumin and curcumin copper complex (1:1) on radiation-induced changes of anti-oxidant enzymes levels in the livers of Swiss albino mice.
TLDR
Under the influence of irradiation, both curcumin and complex treatment protected the decline in the levels of GSH, GST, SOD, catalase and total thiols, and inhibited radiation-induced lipid peroxidation. Expand
Protective effects of curcumin against gamma radiation-induced ileal mucosal damage
TLDR
Curcumin appears to have protective effects against radiation-induced damage, suggesting that clinical transfer is feasible and curcumin as a potential radioprotectant for the ileum goblet cells of the rat. Expand
Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study.
TLDR
Partial support is provided for the antidepressant effects of curcumin in people with major depressive disorder, evidenced by benefits occurring 4 to 8 weeks after treatment. Expand
...
1
2
3
4
5
...