Effect of Crystal Size on the In Vitro Dissolution and Oral Absorption of Nitrendipine in Rats

@article{Xia2010EffectOC,
  title={Effect of Crystal Size on the In Vitro Dissolution and Oral Absorption of Nitrendipine in Rats},
  author={Dengning Xia and Fude Cui and Hongze Piao and Dongmei Cun and Hongyu Piao and Yanbo Jiang and Mei Tao Ouyang and Peng Quan},
  journal={Pharmaceutical Research},
  year={2010},
  volume={27},
  pages={1965-1976}
}
ABSTRACTPurposeTo investigate the effect of crystal size on the dissolution and oral absorption of nitrendipine, a poorly soluble drug, in rats.MethodsFive types of nitrendipine crystal suspensions with different particle sizes (200 nm, 620 nm, 2.7 μm, 4.1 μm, 20.2 μm) were prepared either by the precipitation-ultrasonication or the anti-solvent precipitation method. The simulated intestinal fluid in the fasted state (FaSSIF) was selected as the dissolution medium, and the dissolution behaviors… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES