Effect of Cryopreservation on Canine and Human Activated Nucleus Pulposus Cells: A Feasibility Study for Cell Therapy of the Intervertebral Disc

@inproceedings{Tanaka2013EffectOC,
  title={Effect of Cryopreservation on Canine and Human Activated Nucleus Pulposus Cells: A Feasibility Study for Cell Therapy of the Intervertebral Disc},
  author={Masahiro Tanaka and Daisuke Sakai and Akihiko Hiyama and Fumiyuki Arai and Daisuke Nakajima and Tadashi Nukaga and Tomoko Nakai and Joji Mochida},
  booktitle={BioResearch open access},
  year={2013}
}
It has been shown that coculture of bone marrow-derived stromal cells (BMSCs) with intervertebral disc (IVD) nucleus pulposus (NP) cells significantly activates the biological characteristics of NP cells in animal models and in humans. We therefore predicted that activated NP cells would be a useful graft source for cellular transplantation therapy in the treatment of degenerative IVDs. However, the activation protocol is based on fresh isolation and activation of NP cells, which limits the… CONTINUE READING
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