Effect of Compressive Strain on Cell Viability in Statically Loaded Articular Cartilage

@article{Torzilli2006EffectOC,
  title={Effect of Compressive Strain on Cell Viability in Statically Loaded Articular Cartilage},
  author={Peter A Torzilli and X.-H. Deng and Melissa A. Ramcharan},
  journal={Biomechanics and Modeling in Mechanobiology},
  year={2006},
  volume={5},
  pages={123-132}
}
Physiological loading of articulating joints is necessary for normal cartilage function. However, conditions of excessive overloading or trauma can cause cartilage injury resulting in matrix damage and cell death. The objective of this study was to evaluate chondrocyte viability within mechanically compressed articular cartilage removed from immature and mature bovine knees. Twenty-three mature and 68 immature cartilage specimens were subjected to static uniaxial confined-creep compressions of… 
Effect of intermittent cyclic preloads on the response of articular cartilage explants to an excessive level of unconfined compression
TLDR
Low intensity, intermittent cyclic loading was applied to chondral explants prior to an acute unconfined compression on the tissue, showing cyclic preloading increased the proteoglycan content and mechanically stiffened the explants, making them more resistant to matrix damage and cell death under 25 MPa of unconfining compression up to 14 days.
Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death.
Impact induced failure of cartilage-on-bone following creep loading: a microstructural and fracture mechanics study.
Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers
TLDR
The mechanism of trauma determines the type of chondrocyte death and the potential for post‐injury inflammation, as indicated by a blunt impact model based on a cartilage explant model.
Repeated measurement of mechanical properties in viable osteochondral explants following a single blunt impact injury
TLDR
A repeated measures methodology reliably detected changes in the mechanical behaviour of viable osteochondral explants after a single impact injury.
Cartilage collagen matrix reorientation and displacement in response to surface loading.
An investigation of collagen fiber reorientation, as well as fluid and matrix movement of equine articular cartilage and subchondral bone under compressive mechanical loads, was undertaken using
Viability and apoptosis of human chondrocytes in osteochondral fragments following joint trauma.
TLDR
Findings indicate the presence of both necrotic and apoptotic chondrocytes after joint injury and may provide further insight into the role of chONDrocyte death in post-traumatic arthritis.
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TLDR
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TLDR
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TLDR
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