Effect of Commonly Used Organic Solvents on the Kinetics of Cytochrome P 450 2 B 6-and 2 C 8-Dependent Activity in Human Liver Microsomes

@inproceedings{2007EffectOC,
  title={Effect of Commonly Used Organic Solvents on the Kinetics of Cytochrome P 450 2 B 6-and 2 C 8-Dependent Activity in Human Liver Microsomes},
  author={},
  year={2007}
}
  • Published 2007
The effect of common organic solvents on the activities of various human cytochromes P450 has been reported. However, very little is known about their influence on CYP2B6 and CYP2C8 enzymes. The purpose of this study was to investigate the effect of solvents on the kinetics of representative CYP2B6 (bupropion hydroxylase) and CYP2C8 (paclitaxel hydroxylase) reactions in human liver microsomes. Methanol, ethanol, dimethyl sulfoxide (DMSO), and acetonitrile were studied at increasing volumes (v/v… CONTINUE READING
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